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NCAM1 Mouse mAb

簡要描述:NCAM1 Mouse mAb

  • 產(chǎn)品型號:780025
  • 廠商性質(zhì):生產(chǎn)廠家
  • 更新時(shí)間:2025-08-22
  • 訪  問  量:119
產(chǎn)品詳情
稀釋比
FC-1:100
SwissProt ID
P13591
宿主
Mouse
偶聯(lián)物
Unconjugated
修飾
Unmodified
基因 ID
4684
基因名
NCAM1
亞型
IgG2a
克隆性
Monoclonal Antibody
克隆號
FC-906
免疫原
A synthesized peptide derived from human CD56
研究領(lǐng)域
Neuroscience
背景信息
This gene encodes a cell adhesion protein which is a member of the immunoglobulin superfamily. The encoded protein is involved in cell-to-cell interactions as well as cell-matrix interactions during development and differentiation. The encoded protein plays a role in the development of the nervous system by regulating neurogenesis, neurite outgrowth, and cell migration. This protein is also involved in the expansion of T lymphocytes, B lymphocytes and natural killer (NK) cells which play an important role in immune surveillance. This protein plays a role in signal transduction by interacting with fibroblast growth factor receptors, N-cadherin and other components of the extracellular matrix and by triggering signalling cascades involving FYN-focal adhesion kinase (FAK), mitogen-activated protein kinase (MAPK), and phosphatidylinositol 3-kinase (PI3K). One prominent isoform of this gene, cell surface molecule CD56, plays a role in several myeloproliferative disorders such as acute myeloid leukemia and differential expression of this gene is associated with differential disease progression. For example, increased expression of CD56 is correlated with lower survival in acute myeloid leukemia patients whereas increased severity of is correlated with decreased abundance of CD56-expressing NK cells in peripheral blood. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms.
純化方式
Affinity Purified
形式
Liquid
存儲緩沖液
Liquid in 0.01M PBS, pH 7.4, 0.09%(w/v) NaN3
保存溫度
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

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